Application note
Address the extensive heterogeneity of CAR-T drugs to reduce toxicity
High CAR-T heterogeneity leads to decreased efficacy of a CAR-T product, which results in an increased probability to develop side effects in patients
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ImmunoMind helps unravel cell heterogeneity, and discover unprecedented rare cell subpopulations
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The actionable insights provided by ImmunoMind help associate specific cell subpopulations with specific features of a CAR-T product, making it more effective and safe
Takeaways
Background
Numerous T cell subpopulations possess various functional properties and differentiation status, which form T cell heterogeneity. Thus, T cell heterogeneity is a crucial factor at all stages of CAR-T development and manufacturing. An imbalance during CAR-T composition could lead to severe side effects, which would make the product unusable and ineffective.
The composition of the CAR-T product is based on the complicated biology of T cells.
Problem
High CAR-T heterogeneity leads to a low efficacy of the CAR-T drug and cancer patients have significantly lower likelihood of remission.
Successful T cell annotation and the resultant awareness of the precise composition required for an effective CAR-T product, directly influences the quality of the manufacturing process, and the efficiency of the CAR-T drug. Heterogeneous T cell subpopulations and a ratio of CD4+/CD8+ are vital attributes of the CAR-T product. Heterogeneity formed by non T cells is considered to be an artifact of manufacturing.
Solution
ImmunoMind detects the composition of a CAR-T product, and performs high-quality annotation with single-cell precision
The augmented platform provided by ImmunoMind allows you to annotate CAR-T products from your data, delineate cell subpopulations and cell diversity, and calculate cell ratio. This step means that the single-cell expression profiles of CAR-T cells will be matched up with the expression profile of each cell's biological state. ImmunoMind helps companies leverage single-cell multi-omics technologies, which provides medical scientists an opportunity to gain insights which can be utilized to improve a product.
Benefits
You no longer need to perform complicated analyses and long-term calculations! With ImmunoMind you can:
Unravel cell heterogeneity, and isolate unprecedented rare cell subpopulations
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Identify cell subpopulations that inhibit the efficacy of CAR-T
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Determine the functional capabilities of the designed product, in order to improve the therapeutic response of CAR-T
Select the best T cell therapy candidates early with ImmunoMind
• UC Berkeley SkyDeck company
• We have already helped drug developers to boost 6 T cell therapies
• Trusted by City of Hope,
MD Anderson Cancer, and others
MD Anderson Cancer, and others
• Partnerships
• Strategic alliances
• Collaborations
• Contract research
Who we are
How we work
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